1/6/2009
Tuesday morning

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1. Pretest weight (42 readings, averaged) 2. 10 weeks of Diet A (or Diet B, or Diet C, in the other two groups)_ 3. Post-diet weight #1 (42 readings, averaged) 4. 10 weeks of uncontrolled non-diet 5. New non-diet baseline weight #2 (42 readings, averaged) 6. 10 weeks of Diet B (or Diet C, or Diet A, respectively) 7. Post-diet weight #2 (42 readings, averaged) 8. 10 weeks of uncontrolled non-diet 9. New non-diet baseline weight #3 (42 readings, averaged) 10. 10 weeks of Diet C (or Diet A, or Diet B, respectively) 11. Post-diet weight #3 (42 readings, averaged)
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Suppose you are interested in differences in weight loss as a function of the several diets. For each person, you have 3 weight-loss values, being the difference between measurements at #1 and #3 above, between #5 and #7, and between #9 and #11. For conceptual simplicity, lets take those as differences between the averaged values. (What _kind_ of averages may also be up for grabs; the median of each set of 42 values might be best, as being relatively uninfluenced by unexpected, and perhaps unaccountable, extreme values for an individual.) These values are in a Latin square structure that can be displayed thus:
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OBJECTIVES: To compare importance of rate of initial weight loss for long term outcome in obese patients and to compare efficacy of two different weight maintenance programmes. DESIGN: Subjects were randomised to either rapid or slow initial weight loss. Completing patients were re-randomised to one year weight maintenance programme of ad lib diet or fixed energy intake diet. Patients were followed up one year later. SETTING: University research department in Copenhagen, Denmark. SUBJECTS: 43 (41 women) obese s (body mass index 27-40) who were otherwise healthy living in or around Copenhagen. INTERVENTIONS: 8 weeks of low energy diet (2 MJ/day) or 17 weeks of conventional diet (5 MJ/day), both supported by an anorectic compound (ephedrine 20 mg and caffeine 200 mg thrice daily); one year weight maintenance programme of ad lib, low fat, high carbohydrate diet or fixed energy intake diet ( 5 kg at follow up. RESULTS: Mean initial weight loss was 12.6 kg (95% confidence inte.
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